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Genes & Heredity: Creating Variation & Inheriting Traits
Creating Variability
Mutation, Recombination and Independent Assortment
 

Asexual Reproduction and Genetic Variation
Single-celled organisms typically have only one set of chromosomesA tightly-wound, rod-shaped DNA-containing structure, with many associated proteins. Chromosomes are located in the nucleus (in eukaryotic cells).. When single-celled organisms reproduce, they do so by a process called binary fission: the cell splits in two[#](Watson, et al. 1994). This is a type of asexual reproduction: only one individual (an ironic term in this context) is involved. After duplicating its single set of chromosomes, the cell elongates and the cell membrane then invaginates at the middle, pinches off, and splits the cell in two (Figure 1). This results in two 'daughter cells', each with the same number and kinds of chromosomes as the original cell. The daughter cells are genetically identical. In some cases these cells can incorporate genetic material from other cells (plasmids, for example)[#](Snustad & Simmons 2005), but the majority of genetic variability comes from mutationA change to the base pair sequence of genetic material (DNA or RNA).. See below for a discussion of mutation as it relates to sexual reproduction.
 

Sexual Reproduction and Genetic Variation
Sexual reproduction involves the joining of two cells into one. This union, of course, combines two sets of genesA hereditary unit consisting of a sequence of DNA that occupies a specific location on a chromosome and determines a particular characteristic in an organism. and can itself create genetic variability. And, as with asexual reproduction, mutations are also a source of variation. But there are two other ways that sexual reproduction generates variation: recombination and the independent assortment of alleles[#](Snustad & Simmons 2005).
 

These sources of variation are discussed in three separate illustrations.

Illustration:
  In order to understand how variation arises, we must first understand how gametes - reproductive cells - are produced. This illustration explains meiotic cell division and shows how genetic recombination (also called crossing over) contributes to genetic variation.    

Genes are made up of smaller molecules strung together in a sequence, much like words are composed of letters. When the sequence of molecules that make up a gene changes, the function of the gene may change as well. This is most often a bad thing, but occasionally a mutation can be beneficial.

If this change occurs during the production of sex cells, the mutation will manifest itself in the offspring and potentially improve the offspring's chances of successfully producing offspring of its own.

Illustration:
  This illustration discusses the structure of DNA and how changes can occur.  

Illustration:
  The independent assortment of alleles was first described by Gregor Mendel, in his work on hybridization of varieties of garden pea. This phenomenon results in a more thorough mixing of maternal and paternal chromosomes than would otherwise be possible. Independent assortment makes more combinations of genes possible, and so increases the chances that a novel combination may arise which improves an individual's chance of surviving and reproducing.  

 
 
 

Figure 1. The process of asexual reproduction in unicellular organisms.

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Copyright © 2007 Michael Kreuzer, Jr.